Fist are farily Useless in the game. They don't require ammo(hahahhaha), there slow and they don't do much damage. In most cases you can just have fun maybe online punching people to death as an insult. There are times when you come across an item that possess you. When you grab this item you will have amazing human strength and be able to take out even Hell Knights with a few punches. Did I mention your basically invincible.
Well as if the game could not get any scarier we get the flashlight. Sometimes its just far to dark to see where your going and it really requires a flashlight. Unlucky for us taking this flashlight out requires us to put our weapon down. The Flashlight can also serve as a club but not recommend for combat.
The pistol is the first weapon you get in the game. It holds 12 bullets at a time and is usefull for much of the game. If you ever wanna conserve ammo for your other weapons use your pistol to take down a few enemies.
Shotgun is my gun of choice and most likely many others. For close combat nothing touches it. Blast threw enemies in 1-2 hits for much of the game. It holds 12 shots, scatter of course. But i wouldn't recommend for long range.
The Machine gun is a rapid firing weapon with 60 shots a clip. Its accurate and good for long and medium range targets. Not the most powerful weapon but a replacement for the pistol over long range.
Very powerful rapid firing heavy duty gun. It holds 60 bullets of pure power to tear apart anything that moves.
One of the UAC best in High-Tech weaponry. If holds 50 Plasma shots a cel. It Takes out demons with ease and is very rapid fire.
Grenades are well.. explosive. Best used when entering rooms from ladders or other ducts of some sort.
Close Range weapon. If you must hack your enemies close range this is your weapon of choice. But over the shotgun I would never use this. And the fact that your most likely gonna get hurt trying to kill just about everything.
Holds 5 Rockets at a time. Packs a powerful punch but is slow firing. Try to stock up on rockets for later enemies. But I don't recommend firing rockets at close range enemies cause you will also take damage.
This is an Experimental weapon created by UAC personal to battle the creatures found behide the portals in the new world. It holds 4 shots of amazing destructive powers. The longer you hold the trigger the more powerful the shot. But if you hold it to long well your gonna get OWNED :p
This weapon requires the souls of fallen enemies to become charged up and ready to use. Once its ready it can take out any number of enemies in the area. As well as destroying almost everything in its path it gathers health which is then given to you. The use of this cube is very important espeically towards the end of the game.